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KMID : 0388220100170010016
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Journal of the Korean Rheumatism Association
2010 Volume.17 No. 1 p.16 ~ p.22
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Vitamin D and Immune Responses
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Kang Seong-Wook
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Abstract
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Vitamins and their metabolites are essential for many physiological processes including immune response. In addition to regulating calcium homeostasis, vitamin D exerts various effects on cells of the immune system, such as macrophages, dendritic cells as well as, B and T cells. Low vitamin D levels are found in patients with autoimmune diseases, which suggest a potential role of vitamin D in autoimmunity. In this review, we discuss the roles of vitamin D in modulating immune responses and the clinical potential of vitamin D metabolites for preventing and treating inflammatory and autoimmune diseases.
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KEYWORD
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Vitamin D, Autoimmunity, Immunomodulation
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